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KMID : 0363320030240010011
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Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 1 p.11 ~ p.20
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Effects of Kangwhalyupung-tang on the Cerebral Neuronal Damage induced by Ischemia
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Lee Seoung-Geun
Moon Byung-Soon
Kim Keong-Yo
Lee Geon-Mok
Sung Kang-Keyng
Lee Dae-Yong
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Abstract
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Objective : Experimental studies have been done to elucidate the effect of kangwhalyupung-tang(KWYPT) on neuronal cell damage induced by brain ischemia.
Method : The cytotoxic effect of ischemia was measured in the MTS assay cultures. MTS assay, INT assay, neurofilament(NF) enzymeimmuno assay(EIA). And the KWYPT on ischemia-induced neurotoxicity were examined by in vitro assays.
Results :
1. The KWYPT protected effectively neuronal cell-death resulted from brain ischemia induced by the treatment of 95%N_2/5%CO_2 for 10 min in those dependent fashion.
2. The KWYPT effectively increased the amount of NF resulting from brain ischemia, induced by the treatment of 95%N_2/5%CO_2 for 15 min in those dependent fashions.
Conclusions : KWYPT protects the brain ischemia-induced neurotoxicity through the increase of cell viability and of neurofilament in dose-dependent manner.
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KEYWORD
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Kangwhalyupung-tang, Cerebral Neuronal Damage
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